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Cells carrying a TP53 mutation accumulate high levels of mutant p53 protein, which drives a dominant-negative effect on the wild-type (WT) copy and the p53 homologs p63 and p73 ( 3). A germline mutation in one TP53 allele results in Li-Fraumeni syndrome, a disorder that increases the risk of cancer occurrence by 70% to 100% over an individual's lifetime ( 2). Unlike RB1, CDKN2A, and PTEN, which are lost in tumors through homozygous deletion, TP53 is most frequently found with a somatic missense mutation in either a heterozygous setting or with a 17p deletion and loss of the second allele ( 1). Easily optimize the color by adjusting the brightness and contrast, or by applying a filter.The most commonly mutated gene in cancer is the transcription factor and tumor suppressor TP53 (p53).

Convert individual files or a batch of files with added effects such as a watermark, text overlay, or rotate your videos to the correct orientation.

Prism cannot be used to break copy-protected videos.

Convert from DVDs by simply adding the DVD, selecting the format and clicking convert.

Preview original videos and what the video output results will be before converting to ensure effect settings including video rotation and captions are set up correctly.

You can even set a specific size for output files. Prism supports everything from HD to high compression for smaller files.

Prism lets you set compression/encoder rates, resolution and frame rate of output files.

MPEG AVI MP4 MOV WMV video file format converter If you can play the video file using Windows Media Player, you can convert it using Prism.

Prism converts avi, mpg, vob, asf, wmv, mp4 and all video formats that have a DirectShow based codec.